Total Synthesis Blog

Today, in the end of the year , some new total synthesis – (+)-Kalafungin. The structure of this target is shown below:

(+)-Kalafungin was isolated for the first time in 1968 from Streptomyces tanashiensis fungi and it exhibits some antibiotic properties. Retrosynthesis of that target is shown below:

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Today, total synthesis of tetracyclic non-natural alkaloid (-)-Lycoricidine. Its enantiomer, (+)-Lycoricidine occurs in plants of the genus Amaryllidaceae (for example in the bulbs of narcissi):

The lycorine-type alkaloids exhibit wide spectrum of biological activities like carcinostatic and antiviral properties. The structure of (-)-Lycoricidine is shown below:

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