Total Synthesis Blog

Today, some interesting tricyclic target, Alboatrin:

Alboatrin has characteristic cis tetrahydofurane-benzenopyrane system. Also, there is ketal moiety present in this molecule what (in my opinion) can be taken advantage in planning of synthesis of Alboatrin (well, in my retrosynthesis I’ve taken advantage of this fact ).

Let’s say something about properties of our target. Well, Alboatrin was isolated from Verticillium alboatrum (some fungi specie, I guess). It exhibits phytotoxic activity, for example – it inhibits the root growth.

Retrosynthesis is shown below:

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Today, in the end of the year , some new total synthesis – (+)-Kalafungin. The structure of this target is shown below:

(+)-Kalafungin was isolated for the first time in 1968 from Streptomyces tanashiensis fungi and it exhibits some antibiotic properties. Retrosynthesis of that target is shown below:

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