Total Synthesis Blog

This target has very long name and it’s molecular structure is really interesting. Let me introduce you spiro-noraristeromycin:

Spiro-noraristeromycin is an analog of naturally occuring aristeromycin. That one was isolated from Streptomyces citricolor bacteria and exhibits antiviral activity.

Let’s see how spiro-noraristeromycin has been synthesised.

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Louisianins are group of pyridine-containing alkaloids isolated from Streptomyces sp. which exhibits many important biological activities (for example anticancer and so on). The structures of Louisianins C and D are shown below:

Ortho strategy has been chosen to construct such trisubstituted pyridines. 4-substituted pyridine seems to be a good starting material in such strategy. Let’s see strategic disconnection in retrosynthetic plan:

Total synthesis should be quick.

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